Association between triglyceride-glucose muscle-loss index (TyG-MLI) and incident cardiovascular disease: a prospective cohort study in the UK biobank.

ABSTRACT:

Background

Insulin resistance and muscle loss are interrelated processes linked to cardiovascular disease (CVD), but they are rarely assessed together. We investigated the association between a novel integrated biomarker-triglyceride-glucose muscle-loss index (TyG-MLI)-and incident CVD in a large prospective cohort.

Methods

A total of 277,418 UK Biobank participants free of CVD at baseline were included. TyG-MLI was calculated as ln[(triglycerides × fasting glucose)/2] × (cystatin C/creatinine). Incident CVD was identified through hospital admissions and death registries. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

Over a median follow-up of 15.1 years, 40,398 participants developed CVD. Crude C

SUBMITTER: Fang Y 

PROVIDER: S-EPMC12805711 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature