S1PR3 Inhibition in alveolar epithelial cells alleviates pulmonary fibrosis by enhancing alveolar barrier function.

ABSTRACT:

Background

Pulmonary fibrosis (PF) is a chronic and progressive respiratory disease characterized by the destruction of the alveolar-capillary barrier. Repeated injury and abnormal repair of alveolar epithelial cells lead to barrier dysfunction and fibroblast activation. The sphingosine-1-phosphate (S1P) and sphingosine-1-phosphate receptor (S1PR) signaling pathways are critical for regulating physiological barrier function. Among the five receptor subtypes, S1PR3 is highly expressed in alveolar epithelial cells, especially after injury, but its specific role in PF remains unclear.

Methods

Public single-cell RNA sequencing datasets were analyzed to examine S1PR3 expression in idiopathic pulmonary fibrosis (IPF) patients. The expression pattern of S1PR3 was validated in bleom

SUBMITTER: Hao M 

PROVIDER: S-EPMC12805736 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature