Murine parainfluenza virus persists in lung innate immune cells sustaining chronic lung pathology.

ABSTRACT: Common respiratory viruses, including the human parainfluenza viruses, threaten human health seasonally and associate with the development of chronic lung diseases. Evidence suggests that these viruses can persist, but the sources of viral products in vivo and their impact on chronic respiratory diseases remain unknown. Using the murine parainfluenza virus Sendai, we demonstrate that viral protein and RNA persist in lung macrophages, type 2 innate lymphoid cells (ILC2s) and dendritic cells long after the infectious virus is cleared. Cells containing persistent viral protein expressed Th2 inflammation-related transcriptomic signatures associated with the development of chronic lung diseases, including asthma. Lineage tracing demonstrated that distinct functional groups of cells contribute t

SUBMITTER: Castro IA 

PROVIDER: S-EPMC12805794 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature