Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits.

ABSTRACT: The liver is a central regulator of cardiometabolic physiology, coordinating processes such as lipid and glucose metabolism, protein synthesis, and detoxification. Genome-wide association studies (GWASs) have identified hundreds of genetic variants associated with cardiometabolic traits, yet their molecular mechanisms in liver cell types remain unclear. Using multiome gene expression and accessible chromatin sequencing on liver samples from 39 individuals, we profiled gene expression and chromatin accessibility in 68,398 nuclei across six primary liver cell types. We identified 306,706 accessible chromatin regions, including 70,884 regions that were undetected in bulk tissue analyses and predominantly represent less abundant cell types. To identify genetic effects on gene regulation in liv

SUBMITTER: Alkhawaja AA 

PROVIDER: S-EPMC12805840 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature