Poor Sensitivity of the Fatty Liver Index Among Lean Individuals.

ABSTRACT:

Introduction

Fatty liver index (FLI) is widely used for detection of steatotic liver disease (SLD) in population studies. While frequently used to study SLD in lean individuals, its performance in this subgroup has not been validated. We hypothesized that FLI, which incorporates body-size measures, is not suitable for studies focusing on lean SLD.

Methods

Data from the National Health and Nutrition Examination Survey 2017-20 were used. Adults with available imaging and variables for FLI calculation were included. SLD was defined by controlled attenuation parameter ≥263 dB/m. Lean status was determined using ethnicity-adjusted body mass index cutoffs. The diagnostic performance of FLI was assessed overall and in lean participants using standard rule-in (≥60) and rule-out (<30

SUBMITTER: Shaik MR 

PROVIDER: S-EPMC12805916 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature