Prognostic Modeling for the Failure of Intravenous Methylprednisolone and the Risk of Visual Disability in AQP4-IgG Positive NMOSD-ON.

ABSTRACT:

Purpose

To identify factors influencing best corrected visual acuity (BCVA) prognosis in patients with AQP4-IgG+ neuromyelitis optica spectrum disorder-related optic neuritis (NMOSD-ON) after treating with high-dose intravenous methylprednisolone.

Methods

A total of 161 intravenous methylprednisolone (IVMP)-treated patients were randomized into training (n = 113) and internal validation (n = 48) sets at a ratio of 7:3. Using Least Absolute Shrinkage and Selection Operator regression, 16 candidate predictors were screened to construct a logistic model to predict follow-up BCVA after six months post-ON attack. Discrimination (area under curve [AUC]), calibration, and clinical net benefit (decision curve analysis [DCA]) were assessed.

Results

The final model included sev

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC12805967 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature