Exploring Trial Endpoints in Geographic Atrophy Based on Localized Functional Changes in Microperimetry and AI-Quantified OCT Biomarkers.

ABSTRACT:

Purpose

The introduction of novel therapeutics for geographic atrophy (GA) highlights the need to define functional correlates of high-risk optical coherence tomography (OCT) biomarkers, in particular retinal-pigment-epithelium (RPE) loss and ellipsoid zone (EZ) loss. We conducted a pointwise structure/function correlation between OCT-based markers and retinal sensitivity (RS) in microperimetry (MP) in GA.

Methods

Patients from the phase III OAKS clinical trial (NCT03525613) examined by OCT (Heidelberg Spectralis) and Macular Integrity Assessment (MAIA, iCare, and Centervue) MP in a 68-point grid were analyzed. Deep-learning-(DL)-based algorithms quantified RPE, EZ loss, and EZ thickness from OCT. Co-registration between MP and OCT was established between each MP stimulus an

SUBMITTER: Birner K 

PROVIDER: S-EPMC12805968 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature