Neuroretinal and Photoreceptor Layer Thickness Reduction Associates With Impaired Cardiovascular Health: The UK Biobank Study.

ABSTRACT:

Purpose

To evaluate layer-specific relationships between retinal architecture, measured by optical coherence tomography (OCT), and cardiovascular health (CVH).

Methods

We analyzed data from 26,230 UK Biobank participants with high-quality spectral-domain OCT images and complete CVH assessments. CVH was quantified using the American Heart Association's Life's Essential 8 (LE8) score. Multivariable linear regression models assessed associations between thickness of eight retinal layers and CVH. The diagnostic performance of retinal layer thickness for identifying poor CVH (LE8 score <50) was evaluated using the area under the receiver operating characteristic curve (AUC).

Results

Each 5 µm increase in ganglion cell complex (β = 0.141; 95% confidence interval [CI], 0.068

SUBMITTER: Peng Y 

PROVIDER: S-EPMC12805974 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature