Enhancing Skin Regeneration during Expansion: A Multicenter Randomized Controlled Trial of Stromal Vascular Fraction and Fat Grafting.

ABSTRACT:

Background

Skin regeneration by means of mechanical stretching is used in reconstructive surgery, but it is often limited by the skin's inherent growth capacity. This multicenter randomized controlled trial evaluated the efficacy of autologous stromal vascular fraction (SVF) transplantation and fat grafting in enhancing skin regeneration during tissue expansion.

Methods

Patients aged 18 to 60 years undergoing skin expansion were randomized to receive SVF transplantation or fat grafting or serve as controls. Participants were also categorized into well-regenerated and poorly regenerated subgroups based on skin texture assessments. Assessments occurred every 4 weeks over 12 weeks, with safety follow-up up to 2 years. The primary outcome was skin thickness change at 12 weeks; s

SUBMITTER: Tan PC 

PROVIDER: S-EPMC12806158 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature