Stimuli-Responsive CuFeTe₂ Nanosheets for Amplified Cuproptosis/Ferroptosis in Triple-Negative Breast Cancer Therapy.

ABSTRACT: Triple-negative breast cancer (TNBC) exhibits high copper and iron uptake, making cuproptosis and ferroptosis promising therapeutic strategies. However, their efficacy is limited by TNBC's intrinsic antioxidant defences. Herein, CuFeTe₂ nanosheets (CFT) with internal tumour microenvironment (TME) responsiveness and external NIR-II mild photothermal enhancement is developed to synergistically overcome this antioxidant defences, amplifying both pathways for improved TNBC therapy. In the acidic TME, CFT releases Fe²⁺ and Cu²⁺. Cu²⁺ reacted with glutathione (GSH) to generate Cu⁺, inhibiting glutathione peroxidase 4 (GPX4), amplifying lipid peroxidation (LPO), and triggering ferroptosis. Cu⁺ also induce dihydrolipoamide S-acetyltransferase

SUBMITTER: Liu M 

PROVIDER: S-EPMC12806277 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature