Differentiated T Lymphocytes and Cancer Cell Mitochondrial Metabolism to Enhance Radioimmunotherapy by a Biomimetic Nanozyme System.

ABSTRACT: Strategies to enhance the anti-tumor immune response through the regulation of cellular metabolism are under intensive investigation. Herein, a T cell membrane (TCM)-coated biomimetic magnesium carbonate (MgCO₃)/Fe-CD hybrid nanozyme system loaded with the Pyruvate kinase M2 (PKM2) activator TEPP-46 (TFMP) is developed, designed to simultaneously induce mitochondrial metabolic reprogramming in both T cells and tumor cells following radiotherapy (RT). The TCM coating enables TFMP to specifically target tumor tissues that highly express PD-L1, where it competitively binds to PD-L1 and thereby alleviates immune checkpoint-mediated T cell suppression. Upon X-ray irradiation, TFMP continuously catalyzes the conversion of radiotherapy-generated hydrogen peroxide into hydroxyl radicals

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12806320 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature