Mapping the Tissue-of-Origins of Mesenchymal Stromal Cells in Injury Repair.

ABSTRACT: Culture-expanded mesenchymal stromal cells (MSCs) are capable of fostering tissue regeneration after transplantation. However, the behavior and physiological role of endogenous MSCs in distal organ repair remain undetermined. In this study, a suite of genetic tools is generated to distinguish MSCs between tissues, and to map their fate in local, proximate, and distal organ repair. By single-cell RNA-sequencing, it is found that the transcriptomic profiles of most non-bone marrow-derived mesenchymal stromal cells (nonBM-MSCs) exhibited high similarities, yet differed from that of bone marrow-derived mesenchymal stromal cells (BM-MSCs), especially in their less abundant secretome. Fate-mapping experiments demonstrated that BM-MSCs do not contribute to the formation of myofibroblasts during f

SUBMITTER: Tang XT 

PROVIDER: S-EPMC12806335 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature