Cortico-Striatal-Midbrain Circuit Dysregulation Underlying MK-801 Induced Impulsivity and the Ameliorative Effects of SEP.

ABSTRACT: Impulsivity is a core pathological feature of various psychiatric disorders including obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, and schizophrenia, which is conceptualized as dysregulated motivational and inhibitory processes. However, the underlying neural mechanism is poorly known. Using an olfactory cued Go/No-Go task, this work finds increased false alarm rate, shortened licking onset latency, elevated licking frequency and reduced inter-trial consistency in mice treated by the NMDAR antagonist (MK-801). Fiber optic recordings reveal MK-801 enhanced cue-evoked neuronal responses in the olfactory bulb (OB), orbitofrontal cortex (OFC), ventral tegmental area (VTA), and nucleus accumbens (NAc), while reducing reward-predictive cue selectivity and increasing N

SUBMITTER: Wang X 

PROVIDER: S-EPMC12806448 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature