Genetically Engineered Light-Responsive In Situ Hydrogels for Immunomodulation and Multimodal Therapy in Metastatic Triple-Negative Breast Cancer.

ABSTRACT: Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer, known for its early onset, strong metastatic tendencies, and poor prognosis. Conventional treatments, including chemotherapy and immunotherapy, often face challenges such as limited efficacy, adverse side effects, and high recurrence rates. To address these limitations, a family of tri-block chimeric proteins, cysteine-tagged silk-elastin-like proteins (cSELPs), is designed to form responsive in situ hydrogels for treating late-stage and metastatic TNBC. These cSELPs are de novo designed to integrate multiple functional protein motifs, including a photothermal agent binding motif, silk-inspired crosslinking motifs, and elastin-like thermo-responsive motifs. This unique sequence design enables the cSELP hy

SUBMITTER: Shen X 

PROVIDER: S-EPMC12806481 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature