Multicharged Zwitterions form Superior Antifouling Interfaces.

ABSTRACT: The long-term prevention of unwanted protein and microbial accumulation on surfaces, including medical devices, remains a significant and largely unresolved challenge. Decades of research into antifouling surfaces have suggested that addressing this issue will require a sustained approach focused on incremental advances in chemical design. The creation of highly hydrophilic surfaces has long been recognized as a key strategy, initially pursued through polyethylene glycol-functionalized coatings. More recently, zwitterionic groups have emerged as effective antifouling moieties. However, the limited chemical diversity of zwitterion-forming chemical entities has constrained further progress. In this study, an alternative approach to enhancing surface hydrophilicity is presented by employing m

SUBMITTER: Meehan D 

PROVIDER: S-EPMC12806515 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature