Tie2-Dependent Mechanisms Influence Leptomeningeal Collateral Dynamics and Reperfusion Following Stroke.

ABSTRACT: Leptomeningeal collateral vessels help redistribute cerebral blood flow following arterial obstruction, reducing tissue damage. This study investigates the Tie2 receptor peptide agonist Vasculotide in a permanent middle cerebral artery occlusion (pMCAO) model. Vasculotide enhanced early diameter enlargement of pre-existing pial collaterals, which may be mediated by structural remodeling, as evidenced by endothelial proliferation. These changes correlated with reduced infarct volume, blood-brain barrier disruption, enhanced blood flow, and functional recovery at 3-28 days post-pMCAO. Conditional endothelial cell (EC)-specific EphA4 knockout (KO) mice exhibited increased Tie2 and Ang-1 expression, mimicking the effects of Vasculotide on collateral size. Simultaneous genetic loss of EC-specif

SUBMITTER: Kaloss AM 

PROVIDER: S-EPMC12806518 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature