Distinct Local and Global Dynamics of α-Helices and β-Sheets in Poly(γ-benzyl-l-glutamate) Peptides.

ABSTRACT: A series of poly(γ-benzyl-l-glutamate) (PBLG) peptides are synthesized, with a broad range of molar masses and different end-groups. By combining static (wide-angle X-ray scattering and ¹³C solid-state nuclear magnetic resonance (NMR)) with dynamic probes (¹³C solid-state NMR, dielectric spectroscopy (DS) as a function of temperature and pressure, and rheology), we could identify distinct local and global dynamics associated with α-helices and β-sheets. The local dynamics reflect segmental relaxations of amorphous segments interrupting the α-helices/β-sheets and at their chain-ends. Two glass temperatures (T_gs) were identified in oligopeptides exhibiting both secondary structures. This is the first report for β-sheet-associated T_g i

SUBMITTER: Spyridakou M 

PROVIDER: S-EPMC12806854 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature