Association between continuous glucose monitoring-derived metrics and coronary plaque vulnerability: A retrospective exploratory analysis.

ABSTRACT:

Background

Impaired glucose homeostasis leads to numerous complications, with coronary artery disease (CAD) being a major contributor to healthcare costs worldwide. Because continuous glucose monitoring (CGM) captures multidimensional features of glucose regulation beyond average glycemia, we evaluated whether CGM-derived indices better predict coronary plaque vulnerability than conventional measures.

Methods

We examined associations between CGM-derived indices and coronary plaque vulnerability assessed by virtual histology-intravascular ultrasound, focusing on the necrotic core (%NC) in humans. We analyzed 14 CGM-derived indices, including average daily risk ratio (ADRR) and autocorrelation-based metrics (AC_Mean and AC_Var), alongside commonly used measures, such as fastin

SUBMITTER: Sugimoto H 

PROVIDER: S-EPMC12807456 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature