Relationship of Topographic Distribution of Geographic Atrophy to Visual Acuity in Nonexudative Age-Related Macular Degeneration.

ABSTRACT:

Purpose

To investigate the topographic distribution of geographic atrophy (GA) and to identify an anatomic endpoint that correlates with visual acuity (VA) in eyes with GA.

Design

Retrospective analysis of a multicenter, prospective, randomized controlled trial.

Participants

The Age-Related Eye Disease Study participants with GA secondary to nonexudative age-related macular degeneration.

Methods

We manually delineated GA on 1654 fundus photographs of 365 eyes. We measured GA areas in 9 subfields on the Early Treatment Diabetic Retinopathy Study (ETDRS) grid and correlated them with VA via a mixed-effects model. We determined the optimal diameter for the central zone by varying the diameter from 0 to 10 mm until the highest r² between GA area in the c

SUBMITTER: Shen LL 

PROVIDER: S-EPMC12807493 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature