Moderation between resting-state connectivity and brain amyloid levels on speed of cognitive and physical function in older adults: Evidence for network-based cognitive reserve.

ABSTRACT: Cognitive and physical function are interrelated in aging. Co-occurring impairments in both domains can be debilitating and lead to increased risk of developing dementia. Amyloid beta (Aβ) deposition in the brain is linked to cognitive decline and is also associated with poorer physical function in older adults. However, significant inter-individual variability exists with respect to the influence of increased brain Aβ concentrations on cognitive and physical outcomes. Identifying factors that explain inter-individual variability in associations between Aβ and clinical outcomes could inform interventions designed to delay declines in both cognitive and physical function. Cognitive reserve (CR) is considered a buffer that allows for cognitive performance that is better than expected for a g

SUBMITTER: Laurienti PJ 

PROVIDER: S-EPMC12807530 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature