Cold Plasma Generates a Localized Inflammatory Response and Promotes Muscle Repair.

ABSTRACT: The FDA-approved Renuvion cold plasma device is currently used for dermal skin tightening procedures and subdermal tightening after liposuction. Anecdotally, patients report improved tissue healing outcomes following treatment. The most likely explanation for this is plasma-generated reactive species which are inflammatory but also activate cellular signaling pathways, stimulate antioxidant responses, and activate immune cells. In this study, we aimed to determine the immediate and long-term molecular effects of a single plasma treatment on surgically injured muscle and the soft tissue envelope. We used RNA sequencing, histology, and immunohistochemistry to determine changes to the tissue following treatment. Neutrophils and mast cells rapidly mobilize 6 h after treatment in conjunction wi

SUBMITTER: Smith CJ 

PROVIDER: S-EPMC12807532 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature