High-sensitivity cardiac troponin I and risk of dementia: the 25-year longitudinal Whitehall II study.

ABSTRACT:

Background and aims

This study hypothesizes that subclinical myocardial injury during midlife, indexed by increases in cardiac troponin I, is associated with accelerated cognitive decline, smaller structural brain volume, and higher risk of dementia.

Methods

Overall, 5985 participants in the Whitehall II study, aged 45-69 who had cardiac troponin I measured by a high-sensitivity assay at baseline (1997-99), were followed until March 2023. The outcome measure was incident dementia; cognitive testing was performed at six waves; and neuroimaging metrics were obtained from magnetic resonance imaging scans in 2012-16. Cox model and linear mixed model were used to examine the association of cardiac troponin with incident dementia and cognitive trajectory. A nested case-control sam

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12807566 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature