Statin use in pregnancy and risk of congenital malformations: a Norwegian nationwide study.

ABSTRACT:

Background and aims

Statins and other lipid-modifying agents (LMAs) have traditionally been contraindicated during pregnancy due to concerns about harmful fetal effects; however, the risks associated with exposure to statins and other LMAs in human pregnancies remain unclear. Therefore, this study aimed to examine the associations between statin and LMA exposure in pregnancy and congenital malformations in offspring, while updating a 2022 meta-analysis with the results from the present study.

Methods

National registry data were linked for all pregnant women in Norway in 2005-18. Associations between first-trimester statin prescription fills and congenital malformations were estimated with mixed-effects logistic regression, adjusting for age, parity, pre-pregnancy folate use,

SUBMITTER: Christensen JJ 

PROVIDER: S-EPMC12807567 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature