Blood pressure, plasma proteins, and cardiovascular diseases: a network Mendelian randomization and observational study.

ABSTRACT:

Background and aims

The biological pathways leading to elevated blood pressure (BP) and subsequent cardiovascular diseases (CVDs) remain incompletely understood. Investigating the proteomic landscape of BP and its overlap with CVD could provide critical insights into the molecular determinants and pathways involved in BP regulation and its subsequent effect on CVD.

Methods

A proteome-wide Mendelian randomization (MR) study was conducted by leveraging genetic instruments from 2007 plasma proteins to assess their causal effects on BP (systolic and diastolic BP). Proteins showing strong associations with BP were further analyzed for potential causal effects on coronary artery disease (CAD) and stroke subtypes. Network MR was performed to estimate the proportion of CVD risk medi

SUBMITTER: Meena D 

PROVIDER: S-EPMC12807568 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature