TEDD: a comprehensive database for translation efficiency dynamics.

ABSTRACT: Translation, a core process in central dogma, is essential for gene expression and determination of biological phenotypes. High-throughput RNA-seq, Ribo-seq, and RNC-seq have enabled large-scale measurement of translation efficiency dynamics, yet systematic quantification and integration of translation efficiency (TE), initiation efficiency (translation ratio, TR), and elongation speed (elongation velocity index, EVI) at both gene and transcript levels across diverse biological contexts remain limited, even though their context-specific regulation-together with associated UTR features-plays key roles in development, homeostasis, and disease. To address this gap, we present TEDD (https://ngdc.cncb.ac.cn/tedd), a comprehensive database for exploring human TE, TR, and EVI with a focus on regu

SUBMITTER: Lei W 

PROVIDER: S-EPMC12807600 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature