PaxDb v6.0: reprocessed, LLM-selected, curated protein abundance data across organisms.

ABSTRACT: Proteomics captures the biological and functional state of cells, condensing complex molecular information into quantitative measurements, yet the reuse of public mass spectrometry (MS) data is impeded by heterogeneous processing and incomplete metadata, limiting its potential to generate new biological insights. These issues restrict reproducibility and cross-study integration, underscoring the need for standardized, high-coverage reference resources. PaxDb addresses this by providing a protein abundance reference at organism- and tissue-level, for the healthy, wild-type state. The v6.0 release integrates 1639 datasets from 392 species, nearly doubling coverage since v5.0, with expanded representation across all kingdoms of life. A new end-to-end MS data processing pipeline enables consis

SUBMITTER: Huang Q 

PROVIDER: S-EPMC12807614 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature