NapRNAdb: a multispecies repository and analytical platform for napRNA discovery and functional annotation.

ABSTRACT: Over 75% of the human genome transcribes noncapped RNAs (napRNAs), which typically function as noncoding RNAs in gene expression regulation. While short napRNAs (e.g. small RNAs) have well-defined transcriptomic roles, long napRNAs with diverse terminal modifications remain poorly characterized. To advance research, we developed NapRNAdb (https://bioinformaticsscience.cn/naprnadb), the first database dedicated to NAP-seq-derived napRNAs, enabling cross-species napRNA transcriptome profiling (40 species). This resource integrates 30 708 napRNAs derived from human and mouse NAP-seq with their expression profiles in multiple biological models, comprising 1016 ACA-napRNAs, 297 CD-napRNAs, 2302 Pol3-napRNAs, 157 polyA-pocket-ACA-napRNAs, 1536 stably expressed linear intron RNAs, 57 small nucleo

SUBMITTER: Xuan J 

PROVIDER: S-EPMC12807620 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature