MGTbind: a comprehensive database of molecular glue ternary interactome.

ABSTRACT: Molecular glues (MGs) are an emerging class of small molecules capable of inducing or enhancing protein-protein interactions, leading to reprograming of cellular events. In recent years, MG discovery has gained significant attention in drug discovery and synthetic biology studies. However, MG discovery remains exceptionally challenging as it continues to rely on serendipity and experimental screening efforts. In order to contribute data resources to facilitate the rational design of MGs, we developed the molecular glue and ternary binding (MGTbind) database, providing comprehensive resources about ternary structures and experimental data for the coverage of MG-engaged interactome. MGTbind database contains 3093 manually curated MGs with their chemical structures and physicochemical propert

SUBMITTER: Zhu J 

PROVIDER: S-EPMC12807621 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature