IID 2025: Physical protein interaction data with detection types, co-purified protein sets, molecular docking, and immune cell networks.

ABSTRACT: Biomedical research benefits from the rapid growth and diversity of experimentally detected protein-protein interactions (PPIs) by gaining important biological insights. However, increasingly dense PPI networks can be challenging to interpret and apply. The 2025 update of the Integrated Interactions Database (IID) enhances accessibility and utility through several new features. We identify and incorporate network structural components from co-purified protein sets, as well as curated and predicted complexes, enabling users to explore network organization beyond binary interactions. Functional, pathway, and disease associations of these components can be analyzed, enabling interactions to be grouped into higher-order structures with known or provisional biological roles. Users can now filte

SUBMITTER: Kotlyar M 

PROVIDER: S-EPMC12807654 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature