PMADS: an integrated database of curated and proteomics-inferred associations between protein post-translational modifications and drug sensitivity.

ABSTRACT: Post-translational modifications (PTMs) are critical regulators of protein stability, localization, and function and have been increasingly implicated in shaping drug responses across diverse diseases. While numerous studies have reported PTM-related mechanisms of drug sensitivity or resistance, no resource has systematically catalogued these associations in disease-specific contexts. Here, we present protein modification and drug sensitivity (PMADS), an integrated database that systematically organizes PTM-drug-disease ternary associations, defined as PTM-centered drug responses in disease context. PMADS catalogues over 4700 curated associations manually extracted from biomedical literature and over 43 800 predicted associations derived from analysis of large-scale proteomics datasets. To

SUBMITTER: Zheng J 

PROVIDER: S-EPMC12807662 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature