MGDB: a curated database for molecular glues.

ABSTRACT: Molecular glues (MGs) represent a unique class of small molecules that modulate protein-protein interactions by altering target protein surface properties, enabling targeted degradation, pathway modulation, or functional control of proteins, including traditionally undruggable targets. Currently, 17 MG-based drugs are approved globally with over 40 in clinical trials, underscoring their therapeutic potential. Despite these advances, the lack of a dedicated database integrating structural, pharmacological, and computational data for such compounds hinders rational drug design. To address this gap, we developed MGDB, a specialized open-access repository integrating rigorously curated multidimensional data for MGs. MGDB contains 7396 curated MGs being sourced from 162 peer-reviewed publicatio

SUBMITTER: Li C 

PROVIDER: S-EPMC12807674 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature