ScVMAP: a comprehensive platform for integrating single-cell chromatin accessibility regions with causal variants.

ABSTRACT: Integrating causal variant effects with single-cell assay for transposase-accessible chromatin with high-throughput sequencing (scATAC-seq) enables a more effective elucidation of the roles and impacts of genetic variations at the single-cell level. With the accumulation of genome-wide association studies and single-cell genomic data, there is an urgent need for comprehensive analysis and efficient exploration of these data to uncover the underlying biological processes. To address this, we developed scVMAP (https://bio.liclab.net/scvmap/), a user-friendly database aiming to provide trait-relevant cell populations at single-cell resolution. The current version of scVMAP has integrated 183 scATAC-seq datasets and 15 884 fine-mapping results, generating more than 32.1 billion trait-cell pair

SUBMITTER: Yu ZM 

PROVIDER: S-EPMC12807677 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature