SVAtlas: a comprehensive single extracellular vesicle omics resource.

ABSTRACT: Extracellular vesicles (EVs) are nanoscale particles released by cells, carrying proteins, nucleic acids, lipids, and metabolites. These vesicles mediate intercellular communication and modulate disease progression across various conditions. Owing to their molecular heterogeneity and the stable bilayer protecting their cargo, EVs serve as valuable tools for early disease detection and personalized therapies. However, traditional bulk EV studies aggregate data, which can mask the distinct molecular profiles of individual EVs critical for targeted diagnostics and treatments, diminishing diagnostic precision. Recent advances in single-EV analysis, leveraging high-resolution sequencing and imaging technologies, have revealed unique molecular signatures. However, a comprehensive database integr

SUBMITTER: Wei Z 

PROVIDER: S-EPMC12807711 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature