Medicines, Diseases, Indications, and Contraindications (MeDIC): a foundational resource to support drug repurposing.

ABSTRACT: Drug databases typically aim to provide reference information on medications and their uses but often lack strict definitions of the terms drug (e.g. approved or a clinical candidate) or disease, and do not focus on any specific context of use. The recent emergence of biomedical knowledge graphs, which integrate diverse biomedical data into a contiguous, harmonized knowledge network, has enabled innovation in drug repurposing (identification of novel uses of existing drugs). This objective has created a new set of requirements and challenges for drug databases to be used for generating high-confidence, testable drug repurposing hypotheses. To address this challenge, we have developed MeDIC as an open, foundational database built from government regulatory sources only, which comprises high

SUBMITTER: DeLuca M 

PROVIDER: S-EPMC12807713 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature