LnCeVar 2.0: an updated resource and web tools for genomic variations disrupting ceRNA networks from single-cell/spatial transcriptomics data.

ABSTRACT: LnCeVar 2.0 (available at http://bio-bigdata.hrbmu.edu.cn/LnCeVar or http://www.bio-bigdata.net/LnCeVar) is an updated database investigating genomic variations that disrupt competing endogenous RNA (ceRNA) networks via single-cell and spatial transcriptomics. Enhancements include expanded data and improved features: (i) 16 937 experimentally supported cancer biomarkers as well as 5785 validated ceRNA interactions and single nucleotide variant (SNV)-ceRNA events, manually curated and linked to key cancer pathogenic processes; (ii) 812 single-cell RNA sequencing/spatial transcriptomics RNA sequencing datasets covering 102 diseases, clinical treatments (e.g. chemotherapy, immunotherapy), and normal tissues; (iii) 5 218 062 single-cell- and spatial-specific SNV-ceRNA events across 2 673 603 c

SUBMITTER: Guo Q 

PROVIDER: S-EPMC12807714 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature