MITE: the Minimum Information about a Tailoring Enzyme database for capturing specialized metabolite biosynthesis.

ABSTRACT: Secondary or specialized metabolites show extraordinary structural diversity and potent biological activities relevant for clinical and industrial applications. The biosynthesis of these metabolites usually starts with the assembly of a core 'scaffold', which is subsequently modified by tailoring enzymes to define the molecule's final structure and, in turn, its biological activity profile. Knowledge about reaction and substrate specificity of tailoring enzymes is essential for understanding and computationally predicting metabolite biosynthesis, but this information is usually scattered in the literature. Here, we present MITE, the Minimum Information about a Tailoring Enzyme database. MITE employs a comprehensive set of parameters to annotate tailoring enzymes, defining substrate and rea

SUBMITTER: Rutz A 

PROVIDER: S-EPMC12807718 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature