CCCdb: a comprehensive manually curated database for cell-cell communication in human and mouse.

ABSTRACT: Cell-cell communication (CCC) is central to the organization, function, and plasticity of multicellular life. Advancing experimental technologies and growing insights into complex multicellular systems and disease microenvironments are driving the demand for experimentally validated CCCs that are systematically and manually curated across diverse tissues, phenotypes, and signaling modalities. Here, we present CCCdb (http://www.licpathway.net/cccdb/index.php), a comprehensive, manually curated database of experimentally validated CCCs for human and mouse. A total of 8467 entries were extracted from thousands of publications, each annotated with standardized information on cell types, tissues, and phenotypes. These entries cover 98 tissues, 1132 cell types, and 548 phenotypes, mediated throu

SUBMITTER: Xu M 

PROVIDER: S-EPMC12807721 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature