SDMap: a comprehensive database of spatial drug perturbation maps.

ABSTRACT: The arrangement patterns and spatial distribution features of cells within tissues are key regulators of drug actions and cellular responses; however, the specific spatial microenvironment that mediates drug actions and efficacy remains to be elucidated. Here, we introduce SDMap (http://bio-bigdata.hrbmu.edu.cn/SDMap/), a database to dissect the spatial distributions of drug-associated cells and spatial contexts that contribute to drug actions. SDMap establishes connections between 5 490 079 spatial locations (spots/cells) derived from 989 slices of 35 human tissues (including disease-state slices) and 538 419 instances across 33 149 drugs. It also offers 10 user-friendly tools for retrieving and analyzing: (i) associations between drug-associated instances and spatial spots/cells, niches,

SUBMITTER: Li F 

PROVIDER: S-EPMC12807743 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature