CNAScope: pan-cancer copy number aberration database with functional annotation and interactive visualization.

ABSTRACT: Copy number aberrations (CNAs) are critical drivers of genomic diversity in oncology, where recurrent CNAs frequently underlie tumorigenesis. However, existing public resources are limited in their somatic CNA specificity, breadth across multiple data modalities, and support for recurrent CNAs with online functional annotation and interactive visualization. Here, we present CNAScope (https://cna.fengslab.com/), a database that curates and functionally annotates over 3 954 361 CNA profiles and 3 946 319 metadata from 810 datasets, 174 464 samples, 3 018 672 single cells, and 764 232 spatial cells/spots, spanning 77 cancer subtypes from eight data sources and 55 cancer initiatives and institutions. CNAScope offers downloadable CNA annotations and interactive visualizations at bin, gene, and

SUBMITTER: Feng X 

PROVIDER: S-EPMC12807756 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature