NPASS database update 2026: comprehensive quantitative composition, bioactivity, and ADME-Tox data of natural products for biomedical research.

ABSTRACT: Bioactive natural products (NPs) are valuable sources for biomedical and various applications. Comprehensive information on their species sources and quantitative properties (including compositions, bioactivities, and toxicities) is of great utility to the research community. Here, we introduced NPASS 3.0 with major updates to significantly expand the previous version and add new data derived from emerging technologies. Firstly, we manually curated new records from 1822 publications to provide: (i) an additional 87 507 quantitative composition records for 4873 NPs in 1030 species and (ii) 878 NPs produced by 341 symbiont organisms and 164 elicitor-responsive organisms, together with an additional 109 engineered organisms and 43 co-culture organisms. Secondly, 34 975 new quantitative toxici

SUBMITTER: Lin H 

PROVIDER: S-EPMC12807772 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature