Remnant cholesterol inflammatory index and MASLD in U.S. adults: mediation role of triglyceride-glucose index.

ABSTRACT:

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD) is driven by dyslipidemia and chronic inflammation. We proposed a novel biomarker, the Remnant Cholesterol Inflammatory Index (RCII), and evaluated its association with MASLD, considering mediation via insulin resistance (TyG index).

Methods

In 3,232 U.S. adults from NHANES 2015-2020 (709 with MASLD), participants were divided into RCII tertiles. Multivariable logistic regression, restricted cubic splines, threshold analysis, subgroup interaction tests, ROC curves, XGBoost SHAP, and mediation analysis were used to assess relationships and mechanisms.

Results

Compared with the lowest tertile, the highest RCII tertile had an OR of 9.578 (95 % CI 6.420-14.291; P < 0.001) for MASLD. A nonli

SUBMITTER: Hang Q 

PROVIDER: S-EPMC12807847 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature