Novel mtDNA methylation-associated prognostic signatures in colorectal cancer.

ABSTRACT:

Background

Given the high morbidity and mortality of colorectal cancer (CRC), as well as its challenging treatment, the present study was conducted to identify reliable prognostic signatures for predicting clinical outcomes.

Methods

This study identified key genes through differential expression analysis and cluster analysis on CRC transcriptomic data from public databases and mitochondrial DNA methylation-related genes (MDM-RGs) from previous literature. Cox analysis and machine learning were used to define prognostic genes and build a prognostic model, followed by the establishment of a nomogram to assess the risk score as a prognostic indicator. Furthermore, the impact of prognostic genes was explored by employing immune infiltration, antitumor immunoassay, medication sen

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12807941 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature