Associations of dietary biotin intake on anxiety and depression: findings from a population-based prospective cohort study.

ABSTRACT:

Background

Some cross-sectional have found the negative association between dietary biotin intake and anxiety and depression symptoms. However, there is still a lack of cohort study in this field. So we conduct this prospective cohort study to investigate the association between dietary biotin intake and anxiety and depression, evaluate their dose-response relationship and the mediating role of inflammation in this process.

Methods

A total of 144,439 UK Biobank participants without baseline anxiety or depression were included. Dietary biotin intake was derived from the 24-h Oxford WebQ data, and anxiety and depression were defined in accordance with the ICD-10 criteria. Cox proportional hazards models and restricted cubic splines (RCS) were used to evaluate longitudinal asso

SUBMITTER: Kong Y 

PROVIDER: S-EPMC12807950 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature