Mechanistic study of glutamine metabolic reprogramming driving non-small cell lung cancer progression via the FGF17-FGFR4 axis mediating epithelial-mesenchymal transition.

ABSTRACT:

Introduction

The reprogramming of glutamine metabolism holds a pivotal position in the energy provision and biosynthesis of tumors. However, the regulatory mechanism of this phenomenon in non-small cell lung cancer (NSCLC) is still not well-understood. NSCLC is a type of malignancy that has a high incidence and mortality rate globally. There is an urgent need to elucidate the role of glutamine metabolism in its pathological mechanism. This clarification may provide theoretical guidance for developing new therapeutic approaches.

Methods

Core targets of glutamine metabolism were screened by integrating single-cell transcriptomic and RNA sequencing data from public databases. Target expression was validated in clinical samples by immunohistochemistry (IHC) and Western blot (WB)

SUBMITTER: Kong Q 

PROVIDER: S-EPMC12807982 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature