Attributable burden of high BMI-related gastrointestinal tract cancers among middle-aged and elderly populations globally, 1990-2021 and projected to 2050: analysis of GBD 2021.

ABSTRACT:

Background

The global burden of gastrointestinal tract cancers (GICs)-specifically liver cancer (LC), colorectal cancer (CRC), gallbladder and biliary tract cancers (GBTCs), and pancreatic cancer (PC)-attributable to high body mass index (BMI) is of increasing concern, especially among middle-aged and elderly populations.

Methods

Using data from the Global Burden of Disease (GBD) Study 1990-2021, we assessed deaths, disability-adjusted life years (DALYs), age-standardized mortality rates (ASMR), and estimated annual percentage changes (EAPC) for LC, GBTCs, CRC, and PC attributable to high BMI in middle-aged and elderly populations. We analyzed regional, national, and Socio-demographic Index (SDI)-stratified patterns and their association with SDI and Human Development Index

SUBMITTER: Yilihaer Y 

PROVIDER: S-EPMC12807987 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature