Mammalian mesenchymal stromal cells enhance zebrafish fin regeneration.

ABSTRACT: Mesenchymal stromal cells (MSCs) possess well-described immunoregulatory properties, yet their capacity to drive regeneration in vertebrates is still debated and their mechanisms of action remain to be fully elucidated. In this study, we used zebrafish larvae, a highly regenerative vertebrate model to study the effects of MSC delivery on caudal fin fold regeneration and monitored macrophage dynamics through live imaging in fluorescent reporter lines. We found that MSCs enhanced fin regeneration by increasing the early recruitment of inflammatory (tnfa +) macrophages at 1-day-post-amputation (dpA), and accelerating resolution between 2 and 3 dpA. Given the established role of prostaglandin E2 (PGE2) in MSC-mediated immunoregulation, we examined its contribution using indomethacin, a cycloox

SUBMITTER: Sapede D 

PROVIDER: S-EPMC12808003 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature