MiR-183-5p modulates inflammatory response and apoptosis in diabetic nephropathy by targeting the TTP.

ABSTRACT:

Objective

To clarify the involvement of miR-183-5p, tristetraprolin (TTP), and inflammatory cytokines in Diabetic nephropathy (DN).

Methods

This retrospective study included 10 patients with DN, 10 patients with type 2 diabetes (T2DM) and 10 controls. Expression levels of miR-183-5p and TTP in T2DM patients and DN patients were detected, and the correlation between miR-183-5p, TTP, and inflammatory cytokines were analyzed. Renal tubular epithelial cells (HK-2) served as the cell model. The expression of TTP and cytokines in the cell cultures was detected using qRT-PCR or ELISA.

Results

miR-183-5p promoted inflammation and apoptosis in the context of hyperglycemia. TTP was identified as the direct target of miR-183-5p. Elevated miR-183-5p expression in HK-2 cells resul

SUBMITTER: Li Z 

PROVIDER: S-EPMC12808012 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature