Sea buckthorn flavonoids attenuate oxidative stress in hepatocellular carcinoma via suppression of PI3K/Akt and JAK pathways.

ABSTRACT:

Objective

Sea buckthorn is rich in flavonoid components that possess significant antioxidant capacity, capable of eliminating free radicals, reducing oxidative damage, and demonstrating inhibitory effects on the proliferation of various cancer cell lines. The total flavonoids of sea buckthorn (SFs) and its monomers have shown their effect in inhibiting the proliferation of human liver cancer cells in vitro, accompanied by a decrease in intracellular oxidative stress indicators. Although current research results indicate that SFs have antioxidant and anti-hepatocellular carcinoma activities, there is still a lack of precise molecular mechanism studies on their role in Hepatocellular carcinoma (HCC).

Methods

SFs were extracted using an ultrasonication-assisted ammonium sulfate

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12808051 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature