Predictive efficacy assessment of serum β₂-microglobulin combined with urinary albumin-to-creatinine ratio for renal function deterioration in type 2 diabetic patients with kidney disease.

ABSTRACT:

Objective

To assess the value of serum β₂-microglobulin (β₂MG) and urinary albumin-to-creatinine ratio (UACR) in predicting short-term renal function decline in patients with type 2 diabetic kidney disease (DKD).

Methods

We retrospectively analyzed 356 patients with diabetic kidney disease who received standard care combined with SGLT-2 inhibitors and were followed for six months at Baoji People's Hospital and Hanzhong People's Hospital. Renal deterioration was defined as a ≥30% decline in estimated glomerular filtration rate (eGFR). Clinical and biochemical indicators were assessed using multivariate logistic regression. Model discrimination and calibration were examined through ROC analysis, Akaike information criterion (AIC), and DeLong testing. An a

SUBMITTER: He Y 

PROVIDER: S-EPMC12808059 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature