Egg-laying ChickenGTEx resource deciphers context-specific regulatory effects on fertility traits.

ABSTRACT: Characterization of the genetic and molecular architecture underlying egg production traits in chickens is essential for improving the rate of genetic gain through intensive artificial selection. Here, to explore the dynamic landscape of regulatory effects across egg-laying stages in chickens, we generated 1272 RNA-seq samples of four tissues, i.e., the hypothalamic-pituitary-ovarian axis and liver, and paired whole-genome sequence data from 358 hens. We detected 1008 genes with stage-specific regulatory effects in at least one tissue excluding the pituitary. Out of them, 12.60, 52.78 and 32.84% were mediated by alterations in cell type composition, transcriptional factor activity, and gene co-expression networks among laying stages, respectively. Out of 80 significant loci associated with

SUBMITTER: Zhu D 

PROVIDER: S-EPMC12808096 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature